Abstract
Abstract This work presents the synthesis and characterization of a dicyanamide-bridged coordination polymer [Co(L)2(dca)]n (1) by using the bidentate NO donor Schiff base ligand (2-methoxy-6-((methylimino)methyl)phenol. Furthermore, the nanoparticles of complex 1 (denoted as nano 1) was prepared by a green grinding approach, which has good water dispersibility. The CVB3 infection mice model was built successfully, followed by nano 1 given for treatment. RT-PCR was used to detect the loading of CVB3 virus after nano 1 treatment. The left ventricular fractional shortening (LVFS) as well as left ventricular ejection fraction (LVEF) were assessed to evaluate the protective effect of cardiac functions after exposed to nano 1. The toxicities of nano 1 on H9C2 and HL-1 cardiomyocytes was evaluated by CCK-8 assay. The hypothesis originated from the experimental observations has been further confirmed by using molecular docking simulation.
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