Abstract
The present study aimed to investigate the antitumor activity of Biochanin A in SK-Mel-28 human malignant melanoma cells. An MTT assay was used to study the cytotoxic effects of Biochanin A. In vitro wound healing and invasion assays were used to investigate the effects on cell migration and invasion. Fluorescence microscopy using acridine orange/propidium iodide was used to study effects on cell morphology and apoptosis. Nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) protein expression levels were determined by western blot analysis. The results indicated that Biochanin A significantly inhibited the growth of SK-Mel-28 cells in a dose and time dependent manner. Treatment of the cells with Biochanin A induced apoptosis in a dose dependent manner. Additionally, Biochanin A led to inhibition of cell migration and invasion in a dose-dependent manner and upregulated the expression of key proteins in the NF-κB and MAPK signaling pathways.
Highlights
Following the publication of the above paper, a concerned reader drew to the Editor’s attention that several figures contained apparent anomalies, in‐ cluding repeated patternings of data within the same figure panels
After having conducted an independent investigation in the Editorial Office, the Editor of Oncology Letters has determined that this paper should be retracted from the Journal on account of a lack of confidence concerning the originality and the authenticity of the data
The authors were asked for an explanation to account for these concerns, but the Editorial Office never received any reply
Summary
Following the publication of the above paper, a concerned reader drew to the Editor’s attention that several figures (spe‐ cifically, Figs. 2, 3 and 4) contained apparent anomalies, in‐ cluding repeated patternings of data within the same figure panels.
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