Abstract
A novel Zn(II)-based metal–organic framework {[Zn(L)](DMF)3}n (1) was prepared by using Zn(II) ions and bifunctional imidazole carboxylate ligands (5-(1H-imidazol-1-yl)isophthalic acid, H2L). Complex 1 is a fluorescent Zn-MOF sensor with high selectivity and sensitivity for the detection of nitrobenzene. KSV can reach 2.875 × 103 M−1. The protective effect of compound 1 on the hypertension was further explored. Firstly, the RT-PCR was performed to explore the influence of compound on vdr expression in vascular endothelial cells. Then, the ELISA assay was conducted to measure the renin and angiotensin II level in vivo after compound treatment. The results obtained from molecular docking and pose scoring software exhibited a possible binding mode of the compound binding to vitamin D receptor, which might provide potential regulation mechanisms for the compound.
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