Abstract
[95%CI 0.65-1.36]). We found no difference in AM at 3-5 years. The active group had lower serum cow’s milk (CM) IgG1 at 6 months than the control (p<0.0001) and this difference was still observed at 3 years (p=0.007). Higher CM-IgG1 levels at 6 months were significantly associated with development of specific IgE (CM, hen’s egg) at 3 years (p<0.05). We found no difference between groups in adverse events. Post-hoc analyses were performed on infants who had not introduced solids < 18 weeks (n=312). In this subgroup, active formula was associated with reduced AM at 3-5 years (n=144; p=0.0334) and lower levels of total-IgE and hen’s egg IgE at 6 months (n=239, p=0.0092 and n=244, p=0.0061) compared with control group.
Highlights
We have for the first time evaluated whether a partially hydrolysed whey based formula combined with specific mixture of prebiotic oligosaccharides would reduce the risk of allergic manifestations (AM) in formula-fed infants at increased risk of allergy
Primary outcome was cumulative incidence of atopic dermatitis (AD) up to 12 months in the key group of interest (KGI), which consisted of those infants that started formula < 28 days of age
We found no difference in AM at 3-5 years
Summary
Prebiotic supplemented whey formula for the prevention of allergic manifestations in high risk infants: a multicentre double-blind randomised controlled trial. Robert Boyle1*, Nick Brown, Wen Chin Chiang, Chua Mei Chien, Michael Gold, Jonathan Hourihane, Jane Peake, Patrick Quinn, Raj Rao, Peter Smith, Mimi Tang, John Ziegler, John Warner. From Food Allergy and Anaphylaxis Meeting 2014 Dublin, Ireland. From Food Allergy and Anaphylaxis Meeting 2014 Dublin, Ireland. 9-11 October 2014
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