RETRACTED ARTICLE: Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection

Lijun Niu,Yanhua Luo,Wenkao Huang,Lihong Chen,Yunsheng Li

doi:10.1186/s12871-021-01417-3

Abstract

BackgroundThe objective of this study was to compare the analgesic potency of oxycodone versus morphine after laparoscopic deep infiltrating endometriosis resection.MethodsFifty patients undergoing laparoscopic deep infiltrating endometriosis resection were randomized to receive oxycodone or morphine intravenous-PCA after surgery. The primary outcome was opioid consumption during the 24 h after surgery. Secondary outcomes included time to first request for analgesia, the number of bolus, pain, sedation, nausea, vomiting, respiratory depression, and bradycardia. The prominent pain that caused patients to press the analgesic device was also recorded.ResultsOxycodone consumption (14.42 ± 2.83) was less than morphine consumption (20.14 ± 3.83). Compared with the morphine group, the total number of bolus (78 vs 123) was less and the average time to first request for analgesia (97.27 ± 59.79 vs 142.17 ± 51) was longer in the oxycodone group. The incidence of nausea was higher in the morphine group than in the oxycodone group at 0–2 h (45.45% vs 17.19%), 2–4 h (50% vs 17.19%),12–24 h (40.91% vs 13.04%) and 0–24 h (39.17% vs 19.13%). The overall incidence of vomiting was higher in the morphine group (27.27% vs 13.92%). There was no difference in visual analogue scale score, the incidence of respiratory depression, and bradycardia between groups. Of the three types of pain that prompted patients to request analgesia, the incidence of visceral pain was highest (59.9%, P < 0.01).ConclusionOxycodone was more potent than morphine for analgesia after laparoscopic endometriosis resection, and oxycodone has fewer side effects than morphine.Name of the registry: Chinese Clinical Trial RegistryTrial registration number: ChiCTR1900021870URL of trial registry record:http://www.chictr.org.cn/edit.aspx?pid=35799&htm=4Date of registration: 2019/3/13 0:00:00

Highlights

The objective of this study was to compare the analgesic potency of oxycodone versus morphine after laparoscopic deep infiltrating endometriosis resection
The demographic variables and operative characteristics, including age, body mass index (BMI), American Society of Anesthesiologists (ASA) class, surgical duration, time of carbon dioxide pneumoperitoneum, length of stay in the post-anaesthesia care unit (PACU), and excision site were statistically insignificant between the groups (Table 1)
The visual analogue scale (VAS) score in group O [interquartile range (IQR), 3(2–3)] was the lower at the 4th hour compared with group M [interquartile range (IQR), 3(2.75–4)] (p < 0.01, Table 2), but there were no significant differences at the other time points (Table 2)

Summary

Introduction

The objective of this study was to compare the analgesic potency of oxycodone versus morphine after laparoscopic deep infiltrating endometriosis resection. Pain is the most prominent symptom of DIE, and there are some studies. Niu et al BMC Anesthesiol (2021) 21:194 about long-term pain control after DIE excision [2, 3], but there is no research on analgesia after laparoscopic DIE resection. The prominent type of pain in the first 24 h after surgery varies from surgery to surgery, and there are no studies on the pain characteristics within 24 h after laparoscopic DIE resection. Oxycodone, which is a semisynthetic μ- and κ-opioid receptor agonist, can provide better analgesia than pure μ-opioid receptor agonists after some surgeries due to the critical role of κ-opioid receptors in the reduction of visceral pain [5,6,7,8]. Its analgesic effect after laparoscopic DIE resection is unknown

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