RETRACTED ARTICLE: Near Infrared Light-Actuated PEG Wrapping Carbon Nanodots Loaded Cisplatin for Targeted Therapy of Lung Cancer Therapy

Abstract

Cancer is one of the incurable diseases in the world. Hence, we have effectively synthesized the PEGlyated carbon nanodots loaded cisplatin PEG-CDs@Pt(IV) for targeted therapy of lung cancer therapy. The PEG-CDs@Pt(IV) confirmed by the electroscopic and spectroscopic methods (TEM, DLS, IR and UV–Vis). The In vitro cytotoxicity of the nanoparticles examined two lung cancers (A549 and HEL-299 cells), and one non-cancer cell line (HUVECs) were used in this study by using MTT assay. The nanoparticles are effectively killing cancer cells without affecting the non-cancerous cells. Further we established the morphological changes were of A549 cancer cells, which clearly displays that the nanoparticles induce apoptosis. By compared with PEG-CDs@Pt(IV) and PEG-CDs@Pt(IV) + NIR-NPs, the NIR mediated nanoparticles effectively induce the apoptosis. Also we examined the apoptosis by using flow cytometry, the outcomes suggested that the using PEG-CDs@Pt(IV) + NIR-NPs ultimately killed the A549 cancer cells with IC50 concentrations and were quantified.