RETRACTED ARTICLE: 3D Cu(II) Cluster-Based Coordination Polymer: Increasing the Activity of Prothrombin and Preventing Postpartum Hemorrhage

Abstract

In the current study, via applying a hybrid-ligand method, a novel Cu(II)-based coordination polymer, formulated as [Cu2(OH)(bib)(bpt)]·H2O (1) (H3bpt = biphenyl-3,4′,5-tricarboxylic acid, bib = 1,4-bis(1-imidazolyl)benzene), has been successfully obtained by a isothermal method. Its treatment effect against postpartum hemorrhage was assessed in the bio-study. Firstly, through the model establishment and compound treatment, the prothrombin activity in the plasma was assessed by measuring the prothrombin time. Next, the levels of the factor XI and IX were also assessed by ELISA (enzyme linked immunosorbent assay detection kit). In addition to this, the prevention activity of the compound on the disseminated intravascular coagulation (DIC) during postpartum hemorrhage was also evaluated by measuring the inflammatory response of the inflammatory cytokines, such as IL-1β (interleukin-1β) and TNF-α (tumor necrosis factor-α). The inflammatory signaling relative expression was assessed via the real time RT-PCR (reverse transcription-polymerase chain reaction) as well. Above all, we can see that the compound has excellent treatment activity on DIC disease by inhibiting p53 and nf-κb relative expression in the endothelial cells.