Retracted: A porous Co(II)‐containing metal–organic framework: Selective CO2 capture and clinical nursing values on the myocardial infarction by regulating the mi‐RNA16 expression

Abstract

AbstractIn the present research, a porous metal–organic framework (MOF) has been synthesized via utilizing 2‐amino[1,1:3,1‐terphenyl]‐4,4,5‐tricarboxylic acid, the amino‐functionalized ligand as the raw material under the solvothermal conditions, and its chemical formula is {[Co3(OH)(ATTCA)2(H2O)]·C2H6NH2·4DMF·H2O} (1). At 273 K, activated MOF (1a) reflects highly selective adsorption of CO2 over CH4 (11.7) and N2 (292.5) and strong CO2‐skeleton interaction. It is significant that the exposure of water vapor does not influence the several carbon dioxide cycles on absorption and release and/or surface area, indicating porous structures have the latent capacity of long‐term use in the wet conditions. In biological research, its therapeutic activity on the myocardial infarction was assessed, and at the same time, the detailed mechanism was investigated. Firstly, real‐time reverse transcription polymerase chain reaction (RT‐PCR) method was conducted to determine the mi‐RNA16 expression levels in the cardiomyocytes. Then, the expression level of the target protein of the mi‐RNA16, XOSC was evaluated with western blotting assay. Furthermore, molecular docking simulation shows that the carboxyl function groups are the origin of the biological activity, which could form multiple binding interactions to the protein.