Abstract

We read with interest the recent article by Juutilainen et al. (1) showing that proliferative retinopathy in both sexes and nonproliferative retinopathy in women independently predict all-cause and cardiovascular disease (CVD)-associated death. The authors have cautiously concluded that the sex difference observed in the association between nonproliferative retinopathy and cardiovascular death needs to be confirmed in larger studies. Indeed, I think the relatively low frequency of retinopathy (23%) and the relatively high cut-off chosen for diagnosing hypertension (blood pressure ≥160/95 mmHg or treatment) could be …

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