Abstract
Liver retinoid levels and the retinyl esters were examined in liver biopsy specimens from 70 patients with alcoholic and nonalcoholic liver diseases. There was a wide variation in the liver retinoid levels. The liver retinoid level was statistically significantly lower in 15 patients with alcoholic liver disease and a depressed Normetest (NT) value of < 65% compared with patients with alcoholic liver disease and a normal NT value of >65% ( P < 0.01). The mean serum retinol level in patients with alcoholic cirrhosis was 0.68 ± 0.38 μmol/l compared with 1.99 ± 1.14 μmol/l in patients with alcoholic fatly liver ( P < 0.03). The relative amount of retinyl oleate was increased in the alcoholic fatty liver compared with the nonalcoholic fatty liver ( P < 0.001).
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