Abstract
Abstract The vitamin D receptor (VDR) belongs to a member of nuclear hormone receptor superfamily. The present study delineated a mechanism of VDR mode of action in prevention of neuronal dysfunction and damage in central nervous system. The in vitro treatment of HT 22 mouse hippocampus neuron with RXR agonist retinoic acid was found to modulate VDR. The stilbenes and vitis vinifera were also found to influence VDR in HT22 cells. Moreover, treatment of HT22 cells with retinoic acid rich carrot extract was found to attenuate paraquat induced damage of HT 22 cells. A study has been initiated to determine mode of action of the compounds and to evaluate mechanism of VDR-RXR interactive signals in attenuation of neuronal dysfunction in hippocampus in dementia and seizures. Acknowledgement. I (SDG) acknowledge Eileen McFadden and Christopher Riley for their support in research. The HT 22 cells were provided by Dr Mark S Kindy (MUSC). I am thankful to Dr Sebastiano Gattoni- Celli (MD) for his suggestions.We are thankful to the MUSC research endeavors.
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