Abstract
Isotretinoin is a synthetic form of vitamin A that has been used in the United States since 1983 mainly for the treatment of severe cystic acne. Long-term therapy with low-dose isotretinoin has also been used for prevention of basal cell carcinoma and treatment of cutaneous T-cell lymphomas, and all-trans-retinoic acid (ATRA) has been used in patients with acute promyelocytic leukemia (APML).
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