Abstract
Retinoic acid is a weak promoter of skin tumorigenesis in Charles River CD-1 mice. Multiple papillomas were seen in 17% of the mice treated 3 times weekly with 5.1 μg retinoic acid for 20 weeks after initiation by a single treatment with 50 μg 7,12-dimethylbenz[ a]anthracene (DMBA). These results suggest the necessity of a more thorough evaluation of retinoids as tumor promoters before their serious consideration as anti-cancer agents in man.
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