Abstract
Two revertant cell lines were obtained by treatment of bovine papillomavirus type 1 (BPV-1) DNA-transformed cell lines B3 and BF3 with 5 muM of all-trans-retinoic acid (RA) for 10 weeks. The revertant cells were devoid of detectable viral DNA, no longer exhibited a transformed morphology and lost the ability to form multilayered transformed foci. They replicated with a population doubling time of 16-18 hours, which was also characteristic of the C127, B3 and BF3 cells. They attained a similar saturation density as the C127 cells. However, the revertant cells were at least 5- to 7-fold more resistant than the parental C127 cells to neoplastic transformation induced by BPV-1 DNA.
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