Abstract
SummaryEvidence is presented that retinoic acid-induced anchorage dependent growth of HeLa cells is cell cycle dependent. Spinner cultures of retinoic acid-inhibited cells were blocked in the G1 phase and this block was reversed by simultaneous removal of retinoic acid and attachment of the cells to a plastic tissue culture surface. Studies with a synchronized cell population demonstrated that the retinoic acid had to be added during or before late S phase if the cells were to be blocked in the subsequent G1 phase. These findings are consistent with the hypothesis that vitamin A establishes normal growth controls to some transformed cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
