Retinoic Acid from the Meninges Regulates Cortical Neuron Generation

Abstract

(Cell 139, 597–609; October 30, 2009) In the paper above, the incorrect units were used to report the amount of all-trans retinoic acid detected in embryonic cerebral cortex. On page 603, “0.74 μmol/mg tissue versus 0.28 μmol/mg tissue” should be “0.74 pmol/mg tissue versus 0.28 pmol/mg tissue.” The correction of this error does not affect the graph in Figure 6 (values were reported as percent of all-trans retinoic acid in control tissues, which included either Foxc1+/lacZ or Foxc1+/+ cortices) and does not change any of the conclusions of the paper. The error occurred when the correct units from the primary data provided by the coauthors who performed the analysis were incorrectly written into the manuscript text. Retinoic Acid from the Meninges Regulates Cortical Neuron GenerationSiegenthaler et al.CellOctober 30, 2009In BriefExtrinsic signals controlling generation of neocortical neurons during embryonic life have been difficult to identify. In this study we demonstrate that the dorsal forebrain meninges communicate with the adjacent radial glial endfeet and influence cortical development. We took advantage of Foxc1 mutant mice with defects in forebrain meningeal formation. Foxc1 dosage and loss of meninges correlated with a dramatic reduction in both neuron and intermediate progenitor production and elongation of the neuroepithelium. Full-Text PDF Open Archive