Abstract
Retinoic acid (RA) plays a key role in naïve T cell differentiation into FOXP3+ Treg cell in the respiratory airways. The present study aims to investigate RA and Treg-related cytokine serum levels, salivary IgA levels, FOXP3 and IL-4 gene expression, and the relationships between RA serum levels and Treg-related cytokines in allergic rhinitis (AR) patients and healthy controls. Salivary IgA and serum IgE, RA, IL-10, and TGF-β concentrations were measured by ELISA in 37 AR patients and 30 age- and sex-matched healthy controls. IL-10 and TGF-β concentrations were significantly less in AR patients than in healthy controls (p< 0.01 and P< 0.0001, respectively). Salivary IgA was significantly greater in patients than in controls (p< 0.05). RA was not significantly different between patients and controls (p> 0.05); however, a significant positive correlation was found between serum RA and both IL-10 and TGF-β in AR patients. Our data suggest that RA may influence AR risk via affecting the TGF-β and IL-10 production.
Highlights
Allergic rhinitis (AR) is an upper airway inflammatory disease with a growing prevalence rate over the past 30 years [1]
The findings in this context are controversial, studies have shown that naive T cell differentiation into TH1, T helper 2 (TH2), and Treg cells could be regulated by Retinoic acid (RA) [14,15,16, 21]
This study aimed to address the role of RA in the development of allergic rhinitis (AR)
Summary
Allergic rhinitis (AR) is an upper airway inflammatory disease with a growing prevalence rate over the past 30 years [1]. Many underlying factors, including genetic background, IgE serum concentration greater than 100 IU/ml before the age of 6 years, stress, nutrition, and vitamins A and D deficiencies are recognized as risk factors for AR [2, 3]. Retinoic acid (RA) plays a key role in naïve T cell differentiation into FOXP3+ Treg cell in the respiratory airways. The present study aims to investigate RA and Treg-related cytokine serum levels, salivary IgA levels, FOXP3 and IL-4 gene expression, and the relationships between RA serum levels and Treg-related cytokines in allergic rhinitis (AR) patients and healthy controls. Methods: Salivary IgA and serum IgE, RA, IL-10, and TGF-β concentrations were measured by ELISA in 37 AR patients and 30 age- and sex-matched healthy controls. Conclusions: Our data suggest that RA may influence AR risk via affecting the TGF-β and IL-10 production
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
