Abstract
Background and aims: The intestine-derived hormone Fibroblast Growth Factor 19 (FGF19) and its mouse ortholog Ffg15 are key regulators of bile acid synthesis and energy metabolism. FGF15/19 expression is induced by bile acid-mediated activation of FXR. Moreover, vitamin A (VA) has been shown to activate Fgf15 in an RXR/FXR-dependent manner in mice. Whether VA derivatives regulate FGF19 in human enterocytes and which nuclear receptors contribute to this regulation is currently unknown.
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