Retinoblastoma Case: Shall we Get A Paramagnetic Trend in Chemotherapy?

Alrxander A Bukhvostov,Dmitry A Kuznetsov,Kirill V Ermakov,Anton S Dvornikov

doi:10.21767/2254-6081.100158

Abstract

We have performed our study on a NEN-treated RB cell culture derived from a real clinical autopsy material. 3.5- year-old male donor has died of a massive complex abdominal trauma being previously RB-diagnosed with NMR and ultrasound tests, tumor located behind the eye globe equator line. This is a first report ever on magnetic isotope effects of metal ions to cause the clear anti-cancer consequences in retinoblastoma cells by depriving them of the DNA repair capabilities. Both molecular mechanism of phenomenon and its possible meaning for retinoblastoma chemotherapy are presented here.

Highlights

DNA Polymerases Beta (DNApolB, EC 2.7.7.7) are the key players in DNA repair scenario which makes them critical for malignant cell survival mechanism [1,2]
Retinoblastoma (RB) is an appropriate object for such an impact due to the DNA repair engaging paths of epigenetic control revealed in this peculiar cancer [8]
Some prophetic predictions regarding a therapeutic validity of epigenic DNA expression control in retinoblastoma (RB) has been publicized lately [8] and confirmed considering the cancer DNA repair machinery as a target once its key part, DNA Polymerase Beta, overexpressed [2,7]

Summary

Introduction

DNA Polymerases Beta (DNApolB, EC 2.7.7.7) are the key players in DNA repair scenario which makes them critical for malignant cell survival mechanism [1,2]. Being predominantly based on experiments with RB cell lines like WERI-RB or Y79, this statement still may be treated as “immature” since the in vivo operating neuro-immune and neuro-endocrine paths are no doubt capable of making an impact on intracellular epigenetic environment. This means a necessity to verify the DNApolB related findings on a donor derived RB specimen. The paramagnetic modulators of a DNApolB function deserves to get incorporated into retinoblastoma chemotherapy strategies

Discussion

Conclusion