Retinal Vascular Oxygen Saturation in Adults With Anisometropia.

Abstract

This study aimed to examine the differences of retinal oxygen saturation between the paired eyes in anisometropia and to further explore the relation between retinal oxygenation and myopia. This was an observational cross-sectional study, with 124 adults with anisometropia included. According to the interocular differences in spherical equivalent (SE), individuals with a difference ≥3.0 D belonged to the ΔSE ≥ 3.0 D group, and those with a difference ≥1.5 D and <3.0 D belonged to the ΔSE <3.0 D group. The ΔSE ≥ 3.0 D group contained 61, and the ΔSE < 3.0 D group contained 64. All were performed examinations of retinal oximetry, SE, axial length (AL), intraocular pressure, central corneal thickness and average keratometry. The median SE and AL were -5.06 (-7.22 ∼ -3.41) D and 25.54 (24.73 ∼ 26.62) mm in the "ΔSE < 3 D" group and -4.25 (-6.88 ∼ -2.09) D and 25.52 (24.49 ∼ 26.45) mm in the other group. The retinal arterial oxygen saturation (SaO2) was 93.97% ± 1.26% in the less myopic eyes and 93.18% ± 1.53% (P < 0.001) in the more myopic eyes. In multivariate analyses, SE and AL were both significantly associated with the SaO2. The SaO2 between anisometropic myopic eyes was different, and it was associated with SE and AL. This study demonstrates a relationship between myopia and retinal vascular oxygenation through a novel retinal oximeter.