Abstract
BackgroundOptical coherence tomography (OCT) is widely used in ophthalmology for viewing the morphology of the retina, which is important for disease detection and assessing therapeutic effect. The diagnosis of retinal diseases is based primarily on the subjective analysis of OCT images by trained ophthalmologists. This paper describes an OCT images automatic analysis method for computer-aided disease diagnosis and it is a critical part of the eye fundus diagnosis.MethodsThis study analyzed 300 OCT images acquired by Optovue Avanti RTVue XR (Optovue Corp., Fremont, CA). Firstly, the normal retinal reference model based on retinal boundaries was presented. Subsequently, two kinds of quantitative methods based on geometric features and morphological features were proposed. This paper put forward a retinal abnormal grading decision-making method which was used in actual analysis and evaluation of multiple OCT images.ResultsThis paper showed detailed analysis process by four retinal OCT images with different abnormal degrees. The final grading results verified that the analysis method can distinguish abnormal severity and lesion regions. This paper presented the simulation of the 150 test images, where the results of analysis of retinal status showed that the sensitivity was 0.94 and specificity was 0.92.The proposed method can speed up diagnostic process and objectively evaluate the retinal status.ConclusionsThis paper aims on studies of retinal status automatic analysis method based on feature extraction and quantitative grading in OCT images. The proposed method can obtain the parameters and the features that are associated with retinal morphology. Quantitative analysis and evaluation of these features are combined with reference model which can realize the target image abnormal judgment and provide a reference for disease diagnosis.
Highlights
Optical coherence tomography (OCT) is widely used in ophthalmology for viewing the morphology of the retina, which is important for disease detection and assessing therapeutic effect
The main reason of abnormal image erroneously detected as normal was that some small macular edema appeared on the top of retinal pigment epithelium (RPE). This kind of Conclusions With OCT data being generated in increasingly larger amounts and captured at higher resolution, there is a strong need for computer assisted analysis to support disease diagnosis and the automatic analysis of OCT images has remained an active field of research
We presented an automatic analysis method of fundus retinal status, based on boundary extraction, morphological characterization, feature quantification and grade evaluation
Summary
Optical coherence tomography (OCT) is widely used in ophthalmology for viewing the morphology of the retina, which is important for disease detection and assessing therapeutic effect. The diagnosis of retinal diseases is based primarily on the subjective analysis of OCT images by trained ophthalmologists. This paper describes an OCT images automatic analysis method for computer-aided disease diagnosis and it is a critical part of the eye fundus diagnosis. The most significant medical contribution of OCT is the ophthalmology area, as it could provide the retinal structure and functional images that no other noninvasive diagnosis. Ophthalmologists diagnose the fundus diseases by analyzing the change of retinal features in OCT images; OCT instruments can produce large amounts of data in a short time, so it is difficult to analyze all data by manual method. Rapid, accurate, objective detection and quantification of retinal features is the key of medical OCT images research and diagnosis of ophthalmic diseases, and this study has important theoretical significance and practical value
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