Abstract
Purpose:To evaluate retinal sensitivity over hard exudates in correlation with the spectral domain optical coherence tomography (SD-OCT) findings in eyes with diabetic retinopathy.Methods:Twelve eyes of 10 patients with hard exudates associated with diabetic retinopathy were enrolled in this study. All subjects underwent a complete ophthalmic examination including SD-OCT (Copernicus, Zawiercie, Poland) and microperimetry (MP1; Nidek Technologies, Padova, Italy). Retinal sensitivity was measured, over the areas with hard exudates and compared to corresponding locations devoid of hard exudates, using a semi-automatic program. The size of the hard exudate plaque was measured using the measurement software in the microperimeter. Retinal thickness in the area of the hard exudates and foveal thickness were measured using SD-OCT.Results:Mean retinal sensitivity over hard exudates was 4.97 ± 4.17 dB which was significantly (P = 0.0001) reduced as compared to locations devoid of hard exudates. No significant correlation (r=-0.23, P = 0.45) was found between the size of the hard exudates and retinal sensitivity. A significant negative correlation was found between retinal sensitivity and retinal thickness at the area of the hard exudates (r=-0.65, P = 0.05), and between retinal sensitivity and foveal thickness (r=-0.91, P = 0.001).Conclusion:In eyes with diabetic retinopathy, retinal sensitivity was reduced due to the presence of hard exudates in the outer retinal layers and retinal thickening but this was not correlated with the size of the hard exudates.
Highlights
IntroductionDiabetic retinopathy is a common complication of Received: 11‐03‐2014
Diabetic retinopathy is a common complication of Received: 11‐03‐2014Accepted: 17‐12‐2014Access this article onlineQuick Response Code: Website: www.jovr.org diabetes mellitus, and remains one of the leading causes of visual impairment and blindness.[1,2,3] The deposition of hard macular exudates is a sight threatening consequence of macular edema in patients with diabetes mellitus.[4,5] Visual impairment has been correlated with the deposition of hard foveal exudates[6,7] which are one of the most common and early clinical signs of diabetic retinopathy
Areas without diabetic retinopathy lesions and without any increase in retinal thickness were used as control points
Summary
Diabetic retinopathy is a common complication of Received: 11‐03‐2014. Quick Response Code: Website: www.jovr.org diabetes mellitus, and remains one of the leading causes of visual impairment and blindness.[1,2,3] The deposition of hard macular exudates is a sight threatening consequence of macular edema in patients with diabetes mellitus.[4,5] Visual impairment has been correlated with the deposition of hard foveal exudates[6,7] which are one of the most common and early clinical signs of diabetic retinopathy. Retinal sensitivity over hard exudates in diabetic retinopathy.
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