Abstract
SummaryAdequate function of the retina is dependent on proper oxygen supply. A number of common sources of blindness go hand in hand with abnormalities in perfusion and alterations in oxygenation. In humans, the inner retina is oxygenated via the retinal circulation.In this talk, a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual‐beam bidirectional Doppler OCT and measurement of oxygen saturation by spectrophotometry is presented. Eight healthy subjects were included in the study and breathed ambient room air and 100%, respectively, while perfusion and oxygenation parameters were measured. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing. A pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O2)/min to 0.88 ± 0.14 μl(O2)/min during breathing of 100% oxygen was calculated.The introduced approach that allows measuring retinal oxygen extraction in humans, may have considerable potential for diagnosis, and risk stratification treatment monitoring in patients with retinal vascular disease.
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