Abstract
PurposeTo determine the significance of retinal oxygen saturation for visual acuity at diagnosis and after anti‐VEGF treatment of central retinal vein occlusion (CRVO).MethodsRetinal oximetry was performed in 91 patients with CRVO at the Department of Ophthalmology, Aarhus University Hospital, and the predictive value of the retinal oxygen saturation in larger retinal vessels for the visual prognosis after anti‐VEGF medication was studied.ResultsAt baseline the oxygen saturation in larger retinal vessels was significantly increased in arterioles and decreased in venules in the affected eye. Best corrected visual acuity (BCVA) showed a significant negative correlation with the oxygen saturation in retinal arterioles and a positive correlation with the oxygen saturation in retinal venules. Multiple linear regression showed that BCVA, but not oxygen saturations, contributed significantly to predicting visual outcome after treatment.ConclusionMeasurement of retinal oxygen saturation may help understanding haemodynamic and visual changes in the acute stages of CRVO. However, retinal oximetry cannot replace measures of retinal function as a predictive parameter for the visual outcome in CRVO after intravitreal anti‐VEGF therapy.
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