Abstract

Purpose: The aim of this study was to assess and compare the optic nerve, retina, and retinal vessel parameters in recovered COVID-19 patients and healthy patients by using optical coherence tomography angiography (OCT-a). Methods: In all, 156 eyes of post-COVID-19 patients and 98 eyes of subjects from a control group were enrolled in our study. BCVA, intra ocular pressure (IOP) measurement, fundus examination, and OCT images, including macular cube, OCT-RNFL, and angio-OCT 6 × 6 mm examinations, were performed for both groups. The measurements were acquired using Swept Source OCT DRI OCT Triton. In the post-COVID-19 group, 762 OCT protocols were obtained. For statistical analysis, parameters from only one eye from each subject were taken. Results: In the measured parameters, no significant differences were observed, i.e., central macular thickness (p = 0.249); RNFL (p = 0.104); FAZ (p = 0.63); and vessel density of superficial retinal vascular plexus in central (p = 0.799), superior (p = 0.767), inferior (p = 0.526), nasal (p = 0.402), and temporal (p = 0.582) quadrants. Furthermore, a slit-lamp examination did not reveal any COVID-19-related abnormalities. Conclusion: OCT examination did not detect any significant changes in morphology or morphometry of the optic nerve, retina, or the retina vessels due to COVID-19.

Highlights

  • The novel coronavirus called SARS-CoV-2 was detected for the first time in December2019 in Wuhan, Hubei province, in the People’s Republic of China

  • This study aimed to assess the presence of possible ophthalmological complications after symptomatic coronavirus disease 2019 by appraising the morphology and morphometry of the optic nerve, retina, and retinal vessels using optical coherence tomography in a group of post-COVID-19 subjects

  • 27 men and 51 women who had been infected with COVID-19 participated in the analysis

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Summary

Introduction

The novel coronavirus called SARS-CoV-2 was detected for the first time in December2019 in Wuhan, Hubei province, in the People’s Republic of China. The novel coronavirus called SARS-CoV-2 was detected for the first time in December. The first patient with confirmed SARS-CoV-2 infection in Poland was reported in March 2020. COVID-19, various extrapulmonary symptoms have been described. These include among others gastrointestinal, cardiovascular, neurological, dermatological, renal, and ocular complications [1,2,3]. It has been documented that ACE2 is a receptor for SARS-CoV-2. Ocular conditions during the course of COVID-19 infection are relatively rare, with a low prevalence of symptoms related to the anterior segment of the eye, such as dry eyes, foreign-body sensation, conjunctivitis, redness, and blurry vision [5]. More severe conditions related to the retina and retina vessels have been described, mainly as case reports

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