Abstract
In recent years, increasing attention has been given to the clinical entity known as cytomegalic inclusion disease or generalized salivary gland virus disease. This multisystem viral disease is characterized histologically by the peculiar giant cells with intranuclear and cytoplasmic inclusions.1The disease is primarily of interest to the pediatrician since it occurs most commonly in the newborn and is manifested by prematurity, jaundice, thrombocytopenia, anemia, hepatosplenomegaly, and neurological involvement.2In addition, these affected infants frequently have chorioretinitis, and the disease therefore becomes of particular interest to the ophthalmologist as well.3-6Because of the chorioretinal findings and the frequent finding of intracranial calcification, clinical differentiation from toxoplasmosis is difficult.3Besides the generalized form in the newborn, it has been reported that the inclusions occur in the salivary glands of 8% to 32% of infants and young children who die from various causes.7 The disease in the
Published Version
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