Abstract
The newt ( Notophthalmus viridescens) retinal ganglion cell body response to crush of the ipsilateral optic nerve was monophasic with a maximum number of 50 to 60% of the cells demonstrating reactive chromatin and nucleolar changes by 14 to 24 days postlesion. The number of cells demonstrating this reactive appearance declined to normal values by 90 days. Administration of a second crush lesion 21 days after the initial lesion prolonged the period of maximal cell reactivity for an additional 18 days beyond that of single-lesion controls. Furthermore, the second lesion prevented the normal decline in some cellular parameters that may reflect increased retinal ganglion cell (RGC) anabolic activity after axonal injury such as increased RGC perikaryal area, nucleolar area and number, and RGC [ 3H]uridine incorporation. These results demonstrated that the newt RGC response to axotomy can be manipulated by repeated axonal lesions separated by an interval of 3 weeks.
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