Abstract
AbstractPhotoreceptor degeneration takes place in a group of inherited retinal dystrophies. In most cases, retinal degeneration courses with the dysfunction and death of photoreceptors, leading to blindness. Currently there is not treatment for this disease. Our group has focused in the study of retinal function during photoreceptor degeneration, as a strategy for the development of neuroprotective approaches to extend the visual function independently of the inherited mutation. We have carried out a systematic study of retinal function and photoreceptor structural modifications along the neurodegenerative process. Single cell recordings and Electroretinogram responses have been recording on retinal tissue under degeneration. Correlation of cell function and retinal structure, as studied by immunocytochemistry and electron microscopy confirms the parallelism between visual function loss and photoreceptor degeneration.
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