Abstract
The cyclic-AMP phosphodiesterase activity was measured in normal and dystrophic rat retinas. By the age of 9–12 (i.e. before the onset of retinal degeneration) the phosphodiesterase activity in the albino dystrophic rat retina was significantly lower than that in an albino sighted rat. However, in the pigmented dystrophic retina the loss of retinal phosphodiesterase activity was secondary to the degeneration. In the normal retina there were two types of phosphodiesterase activity distinguishable kinetically, a low Km and a high Km activity. The loss of overall phosphodiesterase activity in the dystrophic retina could be attributed to loss of the high Km activity.
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