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Abstract
We demonstrate swept source OCT utilizing vertical-cavity surface emitting laser (VCSEL) technology for in vivo high speed retinal, anterior segment and full eye imaging. The MEMS tunable VCSEL enables long coherence length, adjustable spectral sweep range and adjustable high sweeping rate (50–580 kHz axial scan rate). These features enable integration of multiple ophthalmic applications into one instrument. The operating modes of the device include: ultrahigh speed, high resolution retinal imaging (up to 580 kHz); high speed, long depth range anterior segment imaging (100 kHz) and ultralong range full eye imaging (50 kHz). High speed imaging enables wide-field retinal scanning, while increased light penetration at 1060 nm enables visualization of choroidal vasculature. Comprehensive volumetric data sets of the anterior segment from the cornea to posterior crystalline lens surface are also shown. The adjustable VCSEL sweep range and rate make it possible to achieve an extremely long imaging depth range of ~50 mm, and to demonstrate the first in vivo 3D OCT imaging spanning the entire eye for non-contact measurement of intraocular distances including axial eye length. Swept source OCT with VCSEL technology may be attractive for next generation integrated ophthalmic OCT instruments.
Highlights
Optical coherence tomography (OCT) is a non-invasive and non-contact imaging modality that enables two-dimensional cross-sectional and three-dimensional volumetric imaging of tissue architecture [1]
Commercial retinal OCT instruments operate near 840 nm wavelength and at axial scan rates up to 52 kHz
We demonstrate vertical-cavity surface emitting laser (VCSEL) light source technology at 1060 nm wavelengths for high speed ophthalmic OCT imaging
Summary
Optical coherence tomography (OCT) is a non-invasive and non-contact imaging modality that enables two-dimensional cross-sectional and three-dimensional volumetric imaging of tissue architecture [1]. OCT is well suited to image semi-transparent objects and was first applied in ophthalmology, where it has become a clinical standard for diagnosing disease and monitoring treatment. The largest ophthalmic application of OCT is retinal imaging and clinical procedures for retinal diagnosis are well established [2]. Commercial retinal OCT instruments operate near 840 nm wavelength and at axial scan rates up to 52 kHz. OCT enables imaging morphology of the retina including the fovea and optic disk for diagnosis and monitoring of therapeutic response in major diseases such as age related macular degeneration, glaucoma
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