Abstract
BackgroundTo report a case of metastatic hepatocholangiocarcinoma to the vitreous and retina.Case presentationA 70-year-old male, who was recently diagnosed with hepatocholangiocarcinoma, was complaining of floaters in his right eye over the past 5 months and was referred to the Liverpool Ocular Oncology Centre. On presentation, his visual acuity in the right eye was 6/24. Fundus exam revealed a whitish, unilateral, full-thickness retinal lesion at the inferotemporal arcade of his right eye, with vitreous infiltration and subretinal fluid. The patient underwent 25G pars plana vitrectomy with biopsy, resection of the lesion and intravitreal bevacizumab injection. Histopathology testing of the surgical specimens confirmed the diagnosis of metastatic carcinoma to the eye. Two months postoperatively his visual acuity had improved to 6/7.5 and there was no sign of active disease in his right eye, while 9 months postoperatively his visual acuity decreased to 6/9.5 due to developing nuclear sclerotic cataract in his right eye.ConclusionThe current report presents the first case of a hepatocholangiocarcinoma metastasis to the vitreous and retina.
Highlights
BackgroundHepatocellularcarcinoma (HCC) and cholangiocellularcarcinoma (CCC) within the same liver, is designated as hepatocholangiocarcinoma (HCC/CCC) [1]
To report a case of metastatic hepatocholangiocarcinoma to the vitreous and retina.Case presentation: A 70-year-old male, who was recently diagnosed with hepatocholangiocarcinoma, was complaining of floaters in his right eye over the past 5 months and was referred to the Liverpool Ocular Oncology Centre
The current report presents the first case of a hepatocholangiocarcinoma metastasis to the vitreous and retina
Summary
Hepatocellularcarcinoma (HCC) and cholangiocellularcarcinoma (CCC) within the same liver, is designated as hepatocholangiocarcinoma (HCC/CCC) [1]. On presentation to LOOC, best corrected visual acuity (BCVA) was 6/24 in RE and 6/4.8 in left eye Fundus examination of his RE showed a single whitish elevated lesion 3–4 DD in size at the infero-temporal arcade associated with vitreous infiltration and intra- and sub-retinal fluid. The patient was started on cycles of palliative chemotherapy intravenously with gemcitabine 1000 mg/m2 on days 1 and 8 along with cisplatin 70 mg/m2 on day 1, after intraocular metastatic disease was diagnosed. One month postoperatively, his BCVA has improved to 6/ 9.5 in his RE and fundoscopy revealed peripheral retinal haemorrhage and subretinal haemorrhage near the resolving metastatic lesion. The patient underwent in total 8 cycles of palliative chemotherapy with gemcitabine along with cisplatin approximately every 4 weeks but succumbed to widespread metastatic disease 5 weeks after completion of last chemo cycle and one year after the initial diagnosis of the primary disease
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