Abstract
The characteristics of melatonin-binding sites labelled by [ 125I]iodomelatonin in membrane preparations from the tree shrew retina were determined. Specific binding of [ 125I]iodomelatonin to the membrane preparations of tree shrew retina was rapid, stable, saturable, and reversible. Among the indoles tested only 6-chloromelatonin, melatonin and N-acetylserotonin had significant affinities to the [ 125I]iodomelatonin binding site. Scatchard analysis of the membrane preparations revealed a dissociation constant ( K d) of 51.0 ± 16 pM and total number of binding sites ( B max) of 1.97 ± 0.6 fmol/mg protein.
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