Abstract
Two immunosuppressed renal allograft recipients developed reticulum cell sarcoma of the colon. Both tumors were clinically unsuspected. The patients presented with features of diverticulitis with perforation. These are the first documented cases of reticulum cell sarcoma arising in transplant recipients in which the colon represented the dominant site of lymphomatous infiltration, with colonic symptoms as the mode of presentation. Both cytomegalic inclusion disease (CID) and inflammation were present in the tumor. In an attempt to evaluate their possible role in evoking an atypical lymphoid proliferation, intestinal and lymphoid tissues from 8 immuno-suppressed transplant recipients with CID and 9 with major colonic inflammatory processes were examined histologically. Atypical lymphoid proliferation was not observed in association with inflammation and/or CID in any of the 17 cases.
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