Reticulocyte Indexes and their Significance

Abstract

A crucial diagnostic tool for assessing, categorizing, and monitoring the effectiveness of anemia treatment is the reticulocyte count. The quality of erythropoiesis is an intrinsic aspect of the pathophysiology of anemia, and the ability of reticulocyte production would be one of the pivotal factors in the quality of erythropoiesis. However, in this minireview, we explain clearly whether the reticulocyte index’s ability is associated with clinical outcomes. There are several ways to describe the reticulocyte count: as a proportion of all red blood cells, as an absolute count, as a corrected count, as the Reticulocyte Production Index (RPI), or as the Immature Reticulocyte Fraction (IRF). Reticulocyte indexes aid in determining the etiology of anemia. They can distinguish between anemia-related causes and other dyserythropoietic problems.