Abstract
Reticulocytosis was induced in rats depleted of riboflavin for 8 weeks and in their weight-matched (WM) controls by removal of 600ul of blood from the tail vein representing approximately 10% of total blood volume in each rat. Weight-matched rats responded to the bleeding with almost 10% reticulocytosis while the response in RD rats was significantly less (6%). Furthermore, reticulocytes from RD rats took up less iron from an incubation medium containing 59FeCl 3, than reticulocytes from WM rats but the difference was not significant. Incorporation of a tritiated amino acid (3H-Leucine) into total proteins in reticulocytes was significantly less in those from RD than WM rats. The results of the present study suggest that the ineffective response of RD rats to bleeding and the decreased protein synthesis may be secondary to impairment of iron metabolism by riboflavin defiency.
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