Reticular materials as chiral stationary phases in chromatography

Abstract

Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) are reticular materials with outstanding physical and chemical properties. Among these properties, their impressive surface area, highly uniform porosity, adequate synthetic versatility, and stability, have undoubtedly contributed to their success in a wide variety of analytical applications. One of the most recent and interesting applications of MOFs and COFs lies in the chromatographic field, in which they have been incorporated as stationary phases, showing particular success when involved in the resolution of racemic mixtures. For this purpose, a chiral structural component (which is frequently an organic linker) needs to be incorporated in the material to permit its use as chiral stationary phase (CSP). This review attempts to cover a historic overview on the use of MOFs and COFs as CSPs in chromatography, while describing the main applications reported and discussing the synthetic issues of these CSPs, main column configurations, and the analytical performance of the CSPs obtained. [Display omitted]