Abstract
Radiation has been relegated to a palliative role in the management of epithelial ovarian cancer (EOC). Contemporary radiation techniques, including intensity modulated radiation therapy (IMRT), stereotactic body radiation therapy (SBRT), and image-guided radiation therapy, enable conformal treatment that controls local disease with minimal morbidity. Recent studies from multiple institutions support the role of radiation in the ablative treatment of oligometastatic disease and control of locally recurrent and metastatic disease. Effective local treatment with radiation complements the role of systemic therapy in the management of EOC; reduces symptoms and disease burden, and may contribute to a prolonged drug free interval.
Highlights
Radiation has been relegated to a palliative role in the management of epithelial ovarian cancer (EOC)
With the advent of effective chemotherapy, radiation therapy was relegated to a palliative role
Involved field radiation therapy (IFRT) is a general term applied to a limited radiation field treating a defined tumor mass
Summary
Radiation has been relegated to a palliative role in the management of epithelial ovarian cancer (EOC). This perspective posits that radiation remains an effective modality for local control and should be considered complementary to systemic treatment. A growing body of literature, discussed in this article, supports the efficacy of definitive radiation therapy for controlling local disease in patients with EOC, contributing to progression-free survival (PFS) and allowing prolonged periods of freedom from systemic treatment.
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