Retention Prediction System ofO-Aryl,O-(1-methylthioethylidene-amino)phosphates on RP-HPLC

Abstract

Using factor analysis and stepwise linear regression methods, two parameters – CMR and ECCR – were selected from eight solute-related structure parameters as the most retention-influencing parameters. The relationships between the retention data (k ´) and the two structure parameters were established for 13 O-aryl,O-(1-methylthioethylideneamino)phosphate compounds under a wide range of experimental conditions. The retention data (k ´) of another seven compounds with similar structures were predicted using these QSRR equations. Good agreement was obtained between the experimental k ´ values and predicted ones.