Abstract
The retention of seventeen monoamine oxidase inhibitory drugs (mono- and disubstituted derivatives of propargylamine) was determined on a β- cyclodextrin polymer (β-CDP)-coated silica column using methanol-0.05 M K 2HPO 4 (6:4, v/v) as the eluent. The inclusion complex formation between the drugs and a water-soluble β-cyclodextrin polymer was studied by charge-transfer chromatography carried out on reversed- phase TLC layers. The capacity factors were correlated with the various physico-chemical parameters and with the inclusion complex-forming capacity of the monoamine oxidase inhibitory drugs. Calculations indicated that the inclusion complex-forming capacity of the drugs does not influence their retention on a β-CDP column, that is, the water-soluble and water-insoluble β-CDPs show different retention characteristics. The specific hydrophilic adsorption surface of the solutes significantly influences the retention in HPLC. The results suggest that the selectivity of the β-CDP-coated silica support may be different from that of the traditional alkyl-bonded reversed-phase columns.
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