Abstract
Wistar male rats were exposed to green nickel oxide [NiO(G)] aerosols (mass median aerodynamic diameter, 0.6 μm) for 7 h/d, 5 d/wk for up to 12 mo. The average exposure concentration was controlled at 0.3 mg/m3 and 1.2 mg/m3 during the exposure period. Some rats were sacrificed just after the 3- and 6-mo exposures, and others were sacrificed after the termination of the 12-mo exposure.
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