Abstract
Background: In pseudoexfoliative syndrome (PEX), extraocular accumulation is associated with cardiovascular morbidity and mortality. The aim of this study was to investigate the effect of exercise test on corrected QT dispersion (QTcd) and QTcd recovery in PEX. Patients and Methods: A total of 37 patients diagnosed as PEX were included in the study. The control group consisted of 38 patients. The Electrocardiographies (ECG) were taken. The patients were subjected to an exercise test. Results: In the study group, baseline, peak and third minute recovery QTcd values were 41.35 ± 7.27 ms, 65.19 ± 7.83 ms, and 53.61 ± 6.45 ms, respectively. In the control group, baseline, peak and third minute recovery QTcd values were 29.92 ± 4.23 ms, 38.31 ± 4.22 ms and 28.76 ± 3.09 ms, respectively. There was statistically significant difference between the baseline and peak QTcd values of the study group and the control group (t = 8.34224/p < 0.00001, t = 18.55079/p < 0.00001, respectively). In addition, while there was a statistically significant difference between the baseline QTcd and the third minute recovery QTcd in the study group, there was no statistically significant difference between the baseline QTcd value and the third minute recovery QTcd value in the control group as heart rate recovery (t = 8.388558/p < 0.00001, t = 1.967315/p = 0.056668, respectively). Conclusion: All of them were found to have a higher risk in terms of malignant ventricular arrhythmia in the study group, both at rest and with effort, in a statistically significant way compared to the control group.
Highlights
Pseudoexfoliative syndrome (PEX) is characterized by the accumulation of fibrillary extracellular material in some organs, in the eye and out of the eye
All of them were found to have a higher risk in terms of malignant ventricular arrhythmia in the study group, both at rest and with effort, in a statistically significant way compared to the control group
QT dispersion (QTd) is the value obtained by removing the shortest QT time from the longest QT duration in ECG and the value above 60 ms is known to be associated with lethal ventricular arrhythmias [9]
Summary
Pseudoexfoliative syndrome (PEX) is characterized by the accumulation of fibrillary extracellular material in some organs, in the eye and out of the eye. An increase in the chance of arrhythmia was detected in PEX without coronary artery disease. This is thought to be due to changes in autonomic functions [8]. Results: In the study group, baseline, peak and third minute recovery QTcd values were 41.35 ± 7.27 ms, 65.19 ± 7.83 ms, and 53.61 ± 6.45 ms, respectively. Baseline, peak and third minute recovery QTcd values were 29.92 ± 4.23 ms, 38.31 ± 4.22 ms and 28.76 ± 3.09 ms, respectively. There was statistically significant difference between the baseline and peak QTcd values of the study group and the control group (t = 8.34224/p < 0.00001, t = 18.55079/p < 0.00001, respectively). Conclusion: All of them were found to have a higher risk in terms of malignant ventricular arrhythmia in the study group, both at rest and with effort, in a statistically significant way compared to the control group
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