Abstract
A chronic exposure study was designed simulating conditions of modern tunneling construction in which a hyperbaric atmosphere was combined with shotscrete lining methods producing a silicate aerosol at high relative humidity. Monkeys were exposed to either a DQ12 quartz dust concentration of 10 mg/m 3 or a hyperbaric atmosphere at 2500 hPa or a combination of both over 26 months. All quartz-exposed monkeys developed silicosis. In this part of the study the retained mass of quartz dust was determined in the lungs using an O 2 plasma ashing technique. Quartz concentrations of 7.05 ± 2.78 mg/g and 11.14 ± 3.29 mg/g dry lung tissue was found in the quartz-exposed group and in the quartz-exposed group at hyperbaria, respectively. Although the quartz concentration was rather homogeneous in a given lung, differences in the quartz concentration between individual animals indicated a sustained variation in deposition in the lungs and/or clearance from the lungs.
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