Abstract
The use of antioxidant-loaded protein-polysaccharide nanoparticle in stabilizing and delivering curcumin with high internal phase Pickering emulsions is comparatively scarce. Resveratrol (RES)-loaded α-lactalbumin (ALA)-chitosan (CHI) particles were fabricated and used for curcumin-loaded high internal phase Pickering emulsions (HIPPEs) stabilization and delivery. CLSM illustrated that RES-ALA-CHI nanoparticles were effectively adsorbed on oil/water (O/W) interface and a gel-like structure was formed surrounding oil droplets. All HIPPEs exhibited excellent physical stability. CUR retention was 75.4% for HIPPEs with RES-ALA-CHI colloidal particles, which was appreciably higher than that with ALA-CHI colloidal particles (63.9%) after 30days storage. Compared to bulk medium-chain triglyceride (MCT), both lipolysis extent and curcumin (CUR) bioaccessibility were pronouncedly enhanced with HIPPEs-based delivery systems. But both HIPPEs (51.4% and 43.7%) exhibited lower extent of lipolysis than conventional emulsions (90.4%). The occurrence of RES significantly restrained the lipolysis. These results demonstrated that HIPPEs could be excellent delivery systems for delivering lipophilic curcumin.
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