Abstract
Resveratrol, chemically known as 3,5,4'-trihydroxy-trans-stilbene, is a natural polyphenol with promising multi-targeted health benefits. The optimal therapeutic uses of resveratrol are limited due to its poor solubility, rapid metabolism and low bioavailability. To address the issues, we have encapsulated resveratrol inside the nanosized core made of chitosan and coated this core with pectin-shell in order to fabricate a drug delivery vehicle which can entrap resveratrol for a longer period of time. The core–shell nanoparticles fabricated in this way were characterized with the help of Fourier transform infrared spectrometer, field-emission scanning electron microscope, field-emission transmission electron microscopy/selected area electron diffraction, high-resolution transmission electron microscope, dynamic light scattering and zeta potential measurements. In vitro drug release study showed the ability of the core–shell nanoparticles to provide sustained release of resveratrol for almost 30 h. The release efficiency of the drug was found to be pH dependent, and a sequential control over drug release can be obtained by varying the shell thickness. The resveratrol encapsulated in a nanocarrier was found to have a better in vitro antioxidant activity than free resveratrol as determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. This work finally offers a novel nano-based drug delivery system.
Highlights
One of the prime attributes of an efficient drug-delivery vehicle is the controlled drug release rate
Resveratrol-loaded chitosan–pectin core–shell nanoparticles were successfully fabricated by encapsulating resveratrol in cationic chitosan and coating it with anionic pectin-shell through antisolvent precipitation and electrostatic deposition methods
The synthesized core–shell nanoparticles were able to encapsulate an appreciable amount of resveratrol at a loading efficiency greater than 55% with particle yield of 89%
Summary
One of the prime attributes of an efficient drug-delivery vehicle is the controlled drug release rate. To increase the efficiency and therapeutic activity, the drug-delivery system should be made trigger dependent with sustained release behaviour. Various multifunctional nanoparticles with multiple triggers and complex structures have been developed [1,2]. Nano-carriers are being frequently used for drug delivery These nano-carriers can decrease the frequency of administration while maintaining the steady and effective concentration of the drug at the target site [3,4]. During the last few decades, the main focus was on the development of biodegradable nanoparticles for effective drug delivery [6]. Is very high [7] Natural biopolymers such as pectin, alginate and chitosan have recently found wide applications in food and pharmaceutical sectors [8]. The presence of functional groups in the biopolymer structures help to encapsulate bioactive compounds or drugs and to form a cross-linked dense network after encapsulation [9]
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