Abstract
Promoting the browning of white fat may be a potential means of combating obesity. Therefore, in this study, we investigated the effect of resveratrol (RES) on the body weight and browning of white fat in high-fat diet (HFD)-induced obese mice and the potential associated mechanism in vivo. Eight-week-old male mice were randomized to receive different treatments: (1), chow without any additional treatment (chow); (2), chow plus 0.4% resveratrol (chow-RES); (3), HFD without any additional treatment (HFD); and (4), HFD plus 0.4% resveratrol (HFD-RES). After 4 weeks of feeding, additional 8-week-old male recipient mice were randomly allocated to the following 4 treatments: (5), HFD and received feces from chow-fed mice; (6), HFD and received feces from chow-RES-fed mice; (7), HFD and received feces from HFD-fed mice; and (8), HFD and received feces from HFD-RES-fed mice. RES treatment significantly inhibited increases in fat accumulation, promoted the browning of white adipose tissue (WAT) and alleviated gut microbiota dysbiosis in HFD-fed mice. Subsequent analyses showed that the gut microbiota remodeling induced by resveratrol had a positive role in WAT browning, and sirtuin-1 (Sirt1) signaling appears to be a key component of this process. Overall, the results show that RES may serve as a potential intervention to reduce obesity by alleviating dysbiosis of the gut microbiota.
Highlights
Obesity is a severe health problem due to its associations with various adverse health consequences, and the prevalence of obesity has continuously increased worldwide [1]
The results showed remarkable increases in body weight gain, perigonadal visceral adipose tissue and inguinal adipose tissue accumulation in the high-fat diet (HFD)-fed mice (Figure 1A–C)
Sirt1 pathway is involved in the regulator of Sirt1 signaling, our study examined whether the Sirt1 pathway is involved in the underlying mechanism mechanism of of gut gut microbiota-mediated microbiota-mediated host underlying host thermogenesis thermogenesis homeostasis
Summary
Obesity is a severe health problem due to its associations with various adverse health consequences, and the prevalence of obesity has continuously increased worldwide [1]. The current method of weight loss is calorie restriction and exercise. Because this method is difficult to implement and the lost weight is easy to regain, new methods of treating obesity need to be explored [3]. In the search for new obesity treatments, brown adipose tissue (BAT) has gained increasing attention. BAT is primarily distributed around the neck and scapular region of the body, and its function is to decompose and oxidize fatty acids synthesized by triglycerides and to consume calories through non-shivering thermogenesis. Brown fat adipocytes contain multiple small fat droplets and more mitochondria than white adipose tissue (WAT) [4].
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