Abstract
Mast cells are involved in allergic and other inflammatory diseases. The polyphenol resveratrol is known for its anti-inflammatory properties and may be used as nutraceutical in mast cell associated diseases. We analyzed the effect of resveratrol on mast cells in vivo in ovalbumin-induced allergic enteritis as well as experimental colitis in IL-10−/− mice which received resveratrol via drinking water. Treatment with resveratrol prevented the increase in mast cells in both allergic enteritis and chronic colitis in duodenum as well as in colon. Further, it delayed the onset of diseases symptoms and ameliorated diseases associated parameters such as tissue damage as well as inflammatory cell infiltration in affected colon sections. In addition to the findings in vivo, resveratrol inhibited IgE-dependent degranulation and expression of pro-inflammatory cytokines such as TNF-α in IgE/DNP-activated as well as in LPS-activated bone marrow-derived mast cells. These results indicate that resveratrol may be considered as an anti-allergic and anti-inflammatory plant-derived component for the prevention or treatment of mast cell-associated disorders of the gastrointestinal tract.
Highlights
The prevalence of gastrointestinal disorders such as food allergies or inflammatory bowel disease (IBD) has increased in western countries throughout the past decades [1,2]
We found an increase in Mast cells (MC) in experimental IL‐10−/− colitis compared to wildtype mice, which, again, was diminished by resveratrol
We found an increase in MC in experimental IL-10−/− colitis compared to wildtype mice, which, again, was diminished by resveratrol treatment
Summary
The prevalence of gastrointestinal disorders such as food allergies or inflammatory bowel disease (IBD) has increased in western countries throughout the past decades [1,2]. Pharmaceutic medication can be associated with negative side effects such as vomiting or nausea for patients affected [3–5]. Conventional drug therapy is well established and safe [6], generally low compliance has been reported [7–13]. Reasons for low compliance may be high costs, risk of adverse effects or long treatment durations [14]. Natural medication may be associated with none or less adverse effects [4]. Plant substances such as stilbenes, flavonoids and others may be a good alternative and additive therapy option to treat the clinical symptoms of allergy [15,16]. In the context of nutraceuticals, polyphenols such as resveratrol could be of special interest in the near future due to their wide beneficial immunomodulatory effects [17]
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