Resveratrol prevents cisplatin-induced lipid peroxidation in the non-gravid uterus of Sprague-Dawley rats

Abstract

Abstract Background Several studies have demonstrated Cisplatin-induced toxicity on the ovary. However, there is a dearth of literature on the effect of Cisplatin on the non-gravid uterus. Objective This study investigated the effect of cisplatin and supplementation with Resveratrol on the oxidant status and histoarchitecture of the uterus in Sprague-Dawley rats. Materials and methods Forty-five female Sprague–Dawley rats with average weight of 160 g divided into 9 groups (n = 5) were used in this study. Group 1 served as control and received distilled water. Groups 2 and 9 received cisplatin only. Groups 3, 4 and 5 received different doses (5, 10 and 20 mg/kg respectively) of Resveratrol after a single dose of cisplatin. Groups 6, 7 and 8 received different doses (5, 10 and 20 mg/kg respectively) of Resveratrol before cisplatin. At sacrifice, the uterus was analysed for relative organ weight, histopathology and oxidation parameters. Result No significant difference was observed in Glutathione (GSH), Superoxide dismutase (SOD) and Catalase (CAT) levels of rats treated with cisplatin and/or Resveratrol when compared to the control group (p Conclusion This study showed that cisplatin-induced oxidative stress can be prevented by supplementation with Resveratrol in the uterus of Sprague-Dawley rats.