Resveratrol: Potential Application in Sepsis.

Jiajia Li,Sen Lu,Rongan Liu,Xiaobo Huang,Yunping Lan,Yu Lei,Lan Wang,Xiaoxiu Luo,Fuxun Yang,Xiaoting Zeng,Fan Zeng

doi:10.3389/fphar.2022.821358

Jiajia Li, Sen Lu + Show 9 more

Open Access

https://doi.org/10.3389/fphar.2022.821358

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Abstract

Sepsis is a life-threatening organ dysfunction syndrome caused by host response disorders due to infection or infectious factors and is a common complication of patients with clinical trauma, burns, and infection. Resveratrol is a natural polyphenol compound that is a SIRT-1 activator with anti-inflammatory, antiviral, antibacterial, antifungal inhibitory abilities as well as cardiovascular and anti-tumor protective effects. In recent years, some scholars have applied resveratrol in animal models of sepsis and found that it has an organ protective effect and can improve the survival time and reduce the mortality of animals with sepsis. In this study, Medline (Pubmed), embase, and other databases were searched to retrieve literature published in 2021 using the keywords “resveratrol” and “sepsis,” and then the potential of resveratrol for the treatment of sepsis was reviewed and prospected to provide some basis for future clinical research.

Highlights

Sepsis develops following a dysregulated host immune response in patients with clinical trauma, burns, and infection leading to organ dysfunction
Progression to septic shock leads to multiple organ dysfunction syndromes, which is the primary cause of death in critically ill clinical patients, with a mortality rate reaching up to 30%–70% (Singer et al, 2016)
Recent studies have shown that the occurrence of sepsis-induced cardiomyopathy is the result of a variety of factors including myocardial inhibition; mitochondrial dysfunction; oxidative stress; and imbalance of calcium regulation, apoptosis, and adrenoceptors (L’Heureux et al, 2020)

Summary

Introduction

Sepsis develops following a dysregulated host immune response in patients with clinical trauma, burns, and infection leading to organ dysfunction. These included basic studies, including animal experiments and cell experiments, on the effects of resveratrol on the lung, heart, kidney, liver, brain, adrenal gland, gastrointestinal function, and circulatory and immune systems of sepsis models.

Results

Conclusion