Abstract
<p><strong>Abstract</strong></p> <p><strong> </strong></p> Resveratrol is a stilbenoid compound, and a promising potent chemopreventive bioactive agent. Here, we showed for the first time that the combined treatment with resveratrol and TRAIL drastically induced apoptosis in human colon cancer cells when compared to single treatments. Further, resveratrol markedly up-regulated TRAIL receptors, DR5 and DR4 and the results revealed that DR5 siRNA efficiently blocked apoptosis induced by the co-treatment with resveratrol and TRAIL, indicating that DR5 up-regulation by resveratrol helps to enhance TRAIL actions. In addition, the combined effect were tested on normal human cells. All the obtained results suggested that resveratrol is very useful for TRAIL-based treatments for cancer.
Highlights
Resveratrol (RSV, 3,5,4’-trihydroxy-trans-stilbene), (Figure 1) a stilbenoid and a potent chemopreventive bioactive compound, is found in the skin of red grapes, and peanuts
We examined the combined effect of resveratrol and Tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) on apoptosis
Combined treatment proved that pan-caspase inhibitor and specific caspase-3, and -8 inhibitors effectively blocked the apoptosis and this indicating that resveratrol sensitizes Caco cells to TRAIL-induced apoptosis in acaspase-dependent manner
Summary
Resveratrol (RSV, 3,5,4’-trihydroxy-trans-stilbene), (Figure 1) a stilbenoid and a potent chemopreventive bioactive compound, is found in the skin of red grapes, and peanuts. The present study aimed to investigate the anti‐cancer effect of resveratrol in human colon cancer cells. Results show that treatment with resveratrol did not induce apoptosis in Caco cells.
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