Abstract
Our study intends to assess whether resveratrol can ameliorate osteoporosis in mice. Ovariectomized (OVX) mice were established to measure SFRP1 level and SFRP1-siRNA was used to assess its effect on BMSCs osteogenesis. SFRP1 was significantly up-regulated in bone tissues and BMSCs of OVX mice with a gradual decrease during osteogenesis. However, it was not changed during BMSCs differentiation towards osteoclasts. SFRP1 knockdown significantly increased mineralization potentiality, elevated ALP activity and upregulated several osteoblast-specific genes. Moreover, bone loss was reduced in resveratrol-treated OVX mice, possibly through upregulating osteogenesis-associated genes and downregulating SFRP1. In conclusion, resveratrol ameliorates osteogenesis of BMSCs, implying that it might be utilized for treating PMOP.
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